Harnessing the immune system to treat cancer
J. Clin. Invest. Nina Bhardwaj, et al. 117:1130 doi:10.1172/JCI32136 [Go to this article.]

Figure 1
Some of the immunological factors discussed in this Review series that affect tumor development. Cells of both the innate and adaptive arms of the immune system can mediate antitumor immunity, including CTLs, CD4⁺ T cells, B cells, and NK cells. However, as tumors progress, they often develop ways in which to escape immune recognition. For example, they can induce the production of proinflammatory cytokines, the expression of IDO by APCs, and the differentiation of Tregs and various suppressor cells of myeloid origin. TAM, tumor-associated macrophage.