Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice
J. Clin. Invest. Daniela Tirziu, et al. 117:3188 doi:10.1172/JCI32024 [
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Figure 5Echocardiographic analysis of myocardial function in
tTA+/PR39+ mice.
Echocardiographic analysis of LV function after 3 weeks or 6 weeks of PR39 induction or 6 weeks ON/3 weeks OFF (6PN/3OFF). (
A) Posterior wall thickness in diastole (PWTD). (
B) LV end-diastolic dimension (LVEDD). (
C) LV end-systolic dimension (LVESD). (
D) Fraction shortening (FS). Note the myocardial dilatation after 6 weeks’ induction in
tTA+/PR39+ mice maintained after PR39 gene suppression (6ON/3OFF mice). 3 wk,
n = 10 mice/group; 6 wk,
n = 15 mice/group; 6ON/3OFF,
n = 7 mice/group. *
P < 0.05; **
P < 0.001.
