Central insulin action regulates peripheral glucose and fat metabolism in mice
J. Clin. Invest. Linda Koch, et al. 118:2132 doi:10.1172/JCI31073 [Go to this article.]

Figure 4
Central insulin resistance leads to a more severe lipodystrophy compared with peripheral insulin resistance. (A) Average epigonadal fat pad weight of 14-week-old Control^Δper (black bars, n = 19), IR^Δper (white bars, n = 18), Control^Δwb (dark gray bars, n = 18), and IR^Δwb mice (light gray bars, n = 13) mice 30 days after start of inducer administration. Values are mean ± SEM. *P ≤ 0.05; ***P ≤ 0.001 versus control. ANOVA value: WAT, 0.000. (B) Body composition of 14-week-old Control^Δper (n = 9), IR^Δper mice (n = 5), Control^Δwb (n = 8), and IR^Δwb mice (n = 12) measured by nuclear magnetic resonance 30 days after start of inducer administration. Black bars indicate fat mass, white bars indicate lean mass. Values are mean ± SEM. ***P ≤ 0.001 versus control. (C) Free fatty acids of 14-week-old Control^Δper (black bars, n = 3), IR^Δper (white bars, n = 4), Control^Δwb (dark gray bars, n = 10), and IR^Δwb mice (light gray bars, n = 11) mice 7 days after start of inducer administration. Values are mean ± SEM. (D) Serum triglycerides of 14-week-old Control^Δper (black bars, n = 5), IR^Δper (white bars, n = 7), Control^Δwb (dark gray bars, n = 5), and IR^Δwb mice (light gray bars, n = 7) mice 7 days after start of inducer administration. Values are mean ± SEM. *P ≤ 0.05 versus control. (E) Tissue weight of liver, muscle, brain, WAT, kidney, lung, and heart correlated with body weight of 14-week-old Control^Δwb (n = 8–13) and IR^Δwb mice (n = 8–16) 30 days after start of doxycycline administration. Values are mean ± SEM. ***P ≤ 0.001 versus control.