Citations to this article


Despite striking advances in the biomedical sciences, the flow of new drugs has slowed to a trickle, impairing therapeutic advances as well as the commercial success of drug companies. Reduced productivity in the drug industry is caused mainly by corporate policies that discourage innovation. This is compounded by various consequences of mega-mergers, the obsession for blockbuster drugs, the shift of control of research from scientists to marketers, the need for fast sales growth, and the discontinuation of development compounds for nontechnical reasons. Lessons from the past indicate that these problems can be overcome, and herein, new and improved directions for drug discovery are suggested.


Pedro Cuatrecasas


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Citations to this article in year 2010 (9)

Title and authors Publication Year
How to improve R&D productivity: the pharmaceutical industry's grand challenge
SM Paul, DS Mytelka, CT Dunwiddie, CC Persinger, BH Munos, SR Lindborg, AL Schacht
Nature Reviews Drug Discovery 2010
Natural products and ion channel pharmacology
RW Teichert, BM Olivera
Future Medicinal Chemistry 2010
Drug Discovery in Academia- the third way?
J Frearson, P Wyatt
Expert Opinion on Drug Discovery 2010
Process R&D under the magnifying glass: Organization, business model, challenges, and scientific context
HJ Federsel
Bioorganic & Medicinal Chemistry 2010
Overcoming psychological barriers to good discovery decisions
AT Chadwick, MD Segall
Drug Discovery Today 2010
Developing drug prototypes: pharmacology replaces safety and tolerability?
AF Cohen
Nature Reviews Drug Discovery 2010
Cardiovascular Drug Discovery in the Academic Setting: Building Infrastructure, Harnessing Strengths, and Seeking Synergies
SJ Gardell, GP Roth, DP Kelly
Journal of Cardiovascular Translational Research 2010
Potential new drugs for human African trypanosomiasis: some progress at last
MP Barrett
Current Opinion in Infectious Diseases 2010
Presidential Address: Innovation in retrospect and prospect
JA Brander
Canadian Journal of Economics/Revue canadienne d'├ęconomique 2010