Citations to this article


Despite striking advances in the biomedical sciences, the flow of new drugs has slowed to a trickle, impairing therapeutic advances as well as the commercial success of drug companies. Reduced productivity in the drug industry is caused mainly by corporate policies that discourage innovation. This is compounded by various consequences of mega-mergers, the obsession for blockbuster drugs, the shift of control of research from scientists to marketers, the need for fast sales growth, and the discontinuation of development compounds for nontechnical reasons. Lessons from the past indicate that these problems can be overcome, and herein, new and improved directions for drug discovery are suggested.


Pedro Cuatrecasas


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Citations to this article in year 2008 (14)

Title and authors Publication Year
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I Cavero, HR Kaplan
Expert Opinion on Drug Discovery 2008
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M Vierboom, E Breedveld, I Kondova, BA Hart
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RL Ho, CA Lieu
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Application of LC/MS and related techniques to high-throughput drug discovery
A Espada, M Molina-Martin, J Dage, MS Kuo
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Needed: system dynamics for the drug discovery process
S Sirois, LM Cloutier
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NeuroImage 2008
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A Sewing
Drug Discovery Today: Technologies 2008
Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement
I Chopra, C Schofield, M Everett, A O'Neill, K Miller, M Wilcox, JM Frère, M Dawson, L Czaplewski, U Urleb, P Courvalin
The Lancet Infectious Diseases 2008
Zebrafish assays as early safety pharmacology screens: Paradigm shift or red herring?
WS Redfern, G Waldron, MJ Winter, P Butler, M Holbrook, R Wallis, JP Valentin
Journal of Pharmacological and Toxicological Methods 2008