Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II–deficient mice
J. Clin. Invest. Ken-ichi Aihara, et al. 117:1514 doi:10.1172/JCI27095 [
Go to this article.]
Figure 6Immunostaining of proliferative vascular mesenchymal cells with PCNA and BrdU at the vascular wall with and without cuff injury in
HCII+/+ and
HCII+/– mice.
(
A) PCNA staining of the vascular wall with and without cuff injury in
HCII+/+ and
HCII+/– mice. (
B) Quantitative analysis of PCNA-positive cells in intima and media with and without cuff injury in
HCII+/+ (white bars) and
HCII+/– mice (black bars). Values are expressed as mean ± SEM. *
P < 0.05; **
P < 0.01.
n = 8 in each group. (
C) BrdU staining of the vascular wall with and without cuff injury in
HCII+/+ and
HCII+/– mice. (
D) Quantitative analysis of BrdU-positive cells in intima and media with and without cuff injury in
HCII+/+ (white bars) and
HCII+/– mice (black bars) Values are expressed as mean ± SEM. *
P < 0.05; **
P < 0.01.
n = 8 in each group.
