Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II–deficient mice
J. Clin. Invest. Ken-ichi Aihara, et al. 117:1514 doi:10.1172/JCI27095 [
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Figure 5Histopathology of femoral arteries with and without cuff injury in
HCII+/+ and
HCII+/– mice.
(
A) Histological features of uninjured and cuff-injured femoral arteries. Cross sections of uninjured and cuff-injured arteries were obtained on day 28 of cuff injury and stained with Elastica–van Gieson. (
B) Quantitative analysis of arterial intimal area, medial area, adventitial area, intima/media ratio, and adventitia/media ratio with and without cuff injury in
HCII+/+ (white bars) and
HCII+/– mice (black bars). Values are expressed as mean ± SEM. *
P < 0.05; **
P < 0.01.
n = 12 in each group.
