HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir
J. Clin. Invest. Tae-Wook Chun, et al. 115:3250 doi:10.1172/JCI26197 [Go to this article.]

Figure 4
Phylogenetic analysis of HIV env DNA and evidence for cross infection between resting and activated CD4⁺ T cells in patients receiving effective antiviral therapy. (A) Phylogenetic trees of HIV env sequences in resting (blue circles) and activated (red circles) CD4⁺ T cells of 2 representative patients. The outgroup sequences were obtained from unrelated HIV-infected patients. The direction of HIV migration from activated to resting (pink arrow) and from resting to activated (blue arrow) CD4⁺ T cells is shown. The bar indicates genetic distance. (B) The number of viral migration events observed on the phylogenetic trees within the resting and activated CD4⁺ T cell compartments is shown.