Thyrotropin receptor–associated diseases: from adenomata to Graves disease
J. Clin. Invest. Terry F. Davies, et al. 115:1972 doi:10.1172/JCI26031 [Go to this article.]

Figure 2
The TSH-binding pocket and TSHR antibody epitopes. (A) Schematic representation of the TSHR ectodomain showing the major regions (black dots) of TSH binding. Figure adapted with permission from Thyroid (24). (B) Model of the TSH-binding pocket, with TSH ligand making contact with the epitopes within and outside of the LRRs. Figure adapted with permission from Thyroid (28).