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Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight
Michael Rosenbaum, Rochelle Goldsmith, Daniel Bloomfield, Anthony Magnano, Louis Weimer, Steven Heymsfield, Dympna Gallagher, Laurel Mayer, Ellen Murphy, Rudolph L. Leibel
Published in Volume 115, Issue 12
J Clin Invest. 2005; 115(12):3579–3586 doi:10.1172/JCI25977
This article Copyright © 2005, The American Society for Clinical Investigation
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Figure 5

Neuroendocrine function. Percent change (mean ± SEM) from values at Wtinitial of T3, T4, and TSH. Administration of leptin to weight-reduced subjects reversed the significant declines in circulating concentrations of T4 and T3, but not TSH, that are associated with the maintenance of a 10% reduced body weight. Mean ± SEM values at each weight plateau are presented in Supplemental Table 1. *P < 0.05 versus 0; †P < 0.05 versus Wt–10%.

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