Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle
of insulin-resistant offspring
of type 2 diabetic parents
J. Clin. Invest. Katsutaro Morino, et al. 115:3587 doi:10.1172/JCI25151 [
Go to this article.]
Figure 5Insulin signaling data. (
A) IRS-1 serine phosphorylation at Ser307, Ser312, Ser616, and Ser636 in the basal state in control subjects (
n = 10) and IR offspring (
n = 7). (
B) Insulin-stimulated Akt phosphorylation at 20 minutes on Ser473 in control subjects (
n = 5) and IR offspring (
n = 7). Akt phosphorylation was normalized to total Akt protein expression.
