Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle
of insulin-resistant offspring
of type 2 diabetic parents
J. Clin. Invest. Katsutaro Morino, et al. 115:3587 doi:10.1172/JCI25151 [
Go to this article.]
Figure 3Mitochondrial density and gene expression data. (
A) Mitochondrial density in control subjects (
n = 6) and IR offspring (
n = 8), assessed by electron microscopy. The pound symbol (#) indicates muscle fiber; the asterisk indicates mitochondrion. (
B) Mitochondrial protein expressions assessed by Western blotting in control subjects (
n = 6) and IR offspring (
n = 9). Results were normalized to β-actin protein expression. SDH, succinate dehydrogenase; PDH, pyruvate dehydrogenase.
