Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle
of insulin-resistant offspring
of type 2 diabetic parents
J. Clin. Invest. Katsutaro Morino, et al. 115:3587 doi:10.1172/JCI25151 [
Go to this article.]
Figure 2Hyperinsulinemic-euglycemic clamp and intramyocellular lipid content. (
A) Insulin-stimulated rates of muscle glucose metabolism in control subjects (
n = 6) and IR offspring (
n = 8). (
B) Intramyocellular lipid content in soleus muscle of control subjects (
n = 6) and IR offspring (
n = 8), measured by localized
1H MRS.
