Attenuated liver fibrosis in the absence
of B cells
J. Clin. Invest. Tatiana I. Novobrantseva, et al. 115:3072 doi:10.1172/JCI24798 [
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Figure 6B cells mediate antibody-independent effects on CCl
4-induced liver fibrosis. (
A) Mice expressing Epstein-Barr virus–derived protein LMP2a from a gene incorporated at the place of
J elements of the IgH locus that lack both surface and circulating immunoglobulin, (
B)
mIgM-Tg (
JH–/–) mice expressing surface but not secreted Ig, and corresponding WT control mice were gavaged with 1.75 ml/kg of CCl
4 or with mineral oil. One week after the sixth weekly treatment, mice were sacrificed, collagen-specific Sirius red staining of liver sections was performed, and interstitial collagen deposition was quantified. A column of dots represents a series of sections from 1 animal; mean values are shown as red bars.
