Deficits in amygdaloid cAMP-responsive element–binding protein signaling play a role in genetic predisposition to anxiety and alcoholism
J. Clin. Invest. Subhash C. Pandey, et al. 115:2762 doi:10.1172/JCI24381 [Go to this article.]

Figure 4
Anxiety-like behaviors and CREB function in the amygdala of P and NP rats following acute ethanol exposure. (A) The effects of acute ethanol injection (i.p.) on open- and closed-arm activities of P and NP rats in the EPM test. Values represent the mean ± SEM of 5–7 rats in each group. (B) Effect of acute ethanol exposure on p-CREB, PKA-Cα, and NPY protein levels in various amygdaloid structures (CeA, MeA, and BLA) of P and NP rats. Values represent the mean ± SEM of 5 rats in each group. *P < 0.001 versus respective controls.