Go to
JCI Insight
Abstract
There have been exciting recent advances in our understanding of the structural and molecular biology of the glomerular slit diaphragm, as described in a report in this issue of the JCI. These findings, combined with data on the permeability of the basement membrane and evidence that the endothelium may be a more important barrier than often supposed, are allowing a clearer understanding to emerge of how the 3 parts of the glomerular capillary wall jointly determine its functional properties.
Authors
William M. Deen
Figure 1
Options:
View larger image
(or click on image)
Download as PowerPoint
Glomerular capillary wall, consisting principally of a fenestrated endothelium, a basement membrane, and epithelial foot processes. The foot processes form filtration slits spanned by slit diaphragms. Also shown is the endothelial cell coat, or glycocalyx. Some approximate dimensions are (8 , 10 ): minimum diameter of fenestra, 30 nm; GBM thickness, 200–400 nm (depending on species); width of filtration slit, 40 nm. The glycocalyx thickness is uncertain. Figure is not drawn to scale.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)