Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics
J. Clin. Invest. Leo Kager, et al. 115:110 doi:10.1172/JCI22477 [
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Figure 2Unsupervised hierarchical clustering of 25 candidate gene transcripts based on expression in bone marrow ALL cells from 197 newly diagnosed patients with defined ALL subtypes. Each column represents a gene probe set and each row a patient. ALL subtypes are depicted by different colors: red (BHD,
n = 42), blue (BNHD,
n = 58), yellow (
E2A-PBX1,
n = 21), black (T-ALL,
n = 35), and green (
TEL-AML1,
n = 41). The gene cluster highlighted in magenta indicates 7 tightly clustered transcripts. The gene cluster highlighted in purple includes most of the transporters (9 transcripts). Probe set signal values were normalized to the mean across patients, and values for each individual case are represented by a color, with green corresponding to SD (ς) below and red corresponding to SD (ς) above the mean, according to the scale shown.
