Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell–driven B cell responses
J. Clin. Invest. Hyung W. Lim, et al. 114:1640 doi:10.1172/JCI22325 [Go to this article.]

Figure 1
CD4⁺CD25⁺ T cell population and suppression of Ig production. (A) CD4⁺CD25⁺ T cell populations in tonsils. Tonsil mononuclear cells were stained with antibodies to CD4, CD57, CD25, and CD69. The graph shows the combined data (averages and SEM) from 5 different experiments. (B) CD4⁺CD25⁺CD69^– cells, not the total CD4⁺CD25⁺ T cell population, efficiently suppressed the CD57⁺ GC-Th cell_induced B cell production of Ig. CD4⁺CD25⁺ (CD57^–) T cell subsets were sorted and cultured with 10⁵ CD57⁺ GC-Th cells and 10⁵ tonsil CD19⁺ B cells (Total B) for 5 days, followed by ELISA to quantitate the total IgG secreted in the cultures. Representative data (averages and SD of triplicate ELISA measurements) from 5 independent experiments are shown.