Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis
J. Clin. Invest. Luke J. Engelking, et al. 113:1168 doi:10.1172/JCI20978 [
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Figure 7Plasma lipid levels in WT and TgInsig-1 mice fed different amounts of cholesterol (A) or subjected to fasting and refeeding (B). Mice used in A are described in Figure
2; mice used in B are described in Figure
4. Each value is the mean ± SEM of data from four or five mice. The levels of statistical significance (Student’s
t test) between the WT and TgInsig-1 groups are shown as
P values. F, fasted group; R, refed group.
