Mice lacking the syndecan-3 gene are resistant to diet-induced obesity
J. Clin. Invest. April D. Strader, et al. 114:1354 doi:10.1172/JCI20631 [
Go to this article.]
Figure 4Comparison of body weight and percent fat for
syndecan-3–/– and wild-type mice. (
A–
D) Body weight (
A and
C) and percent body fat (
B and
D) of chow-raised (15% fat) wild-type and
syndecan-3–/– mice. Young (12-week-old) mice (male: +/+,
n = 3, and –/–,
n = 3; female: +/+,
n = 7, and –/–,
n = 8) and old (28-week-old) mice (male only; +/+,
n = 10, and –/–,
n = 10) were compared (*
P < 0.05 and **
P < 0.01 compared with wild-type mice;
#P < 0.01 compared with
syndecan-3–/– mice).
