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ResearchIn-Press PreviewCell biologyNephrology
Open Access | 
10.1172/JCI201848
Lactylation-dependent DDX18 nucleolar escape regulates CD44 mRNA stability to drive fibrotic progression in kidney injury
Lijun Dong,1 Jingwen Xie,1 Mengyuan Tao,1 Shuai Liu,2 Yueyang Lu,1 Tianxing Wu,1 Jian Geng,3 Qingyun Chen,4 Xiaoshan Zhao,5 Jianbo Zhao,6 Jia Zhou,7 Honghao Hou,2 Jun Ai,8 Tao Tao,9 and Daming Zuo1
1Institute of Molecular Immunology, Southern Medical University, Guangzhou, China
2School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4Medical Research Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
6Division of Vascular and Interventional Radiology, Department of General Su, Nanfang Hospital, Southern Medical University, Guangzhou, China
7Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
8Department of General Practice, Nanfang Hospital, Southern Medical University, Guangzhou, China
9Sleep and Brain Medicine Center, Shenzhen Hospital, Southern Medical University, Guangzhou, China
Find articles by Dong, L. in: PubMed | Google Scholar
1Institute of Molecular Immunology, Southern Medical University, Guangzhou, China
2School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4Medical Research Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
6Division of Vascular and Interventional Radiology, Department of General Su, Nanfang Hospital, Southern Medical University, Guangzhou, China
7Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
8Department of General Practice, Nanfang Hospital, Southern Medical University, Guangzhou, China
9Sleep and Brain Medicine Center, Shenzhen Hospital, Southern Medical University, Guangzhou, China
Find articles by Xie, J. in: PubMed | Google Scholar
1Institute of Molecular Immunology, Southern Medical University, Guangzhou, China
2School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4Medical Research Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
6Division of Vascular and Interventional Radiology, Department of General Su, Nanfang Hospital, Southern Medical University, Guangzhou, China
7Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
8Department of General Practice, Nanfang Hospital, Southern Medical University, Guangzhou, China
9Sleep and Brain Medicine Center, Shenzhen Hospital, Southern Medical University, Guangzhou, China
Find articles by Tao, M. in: PubMed | Google Scholar
1Institute of Molecular Immunology, Southern Medical University, Guangzhou, China
2School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4Medical Research Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
6Division of Vascular and Interventional Radiology, Department of General Su, Nanfang Hospital, Southern Medical University, Guangzhou, China
7Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
8Department of General Practice, Nanfang Hospital, Southern Medical University, Guangzhou, China
9Sleep and Brain Medicine Center, Shenzhen Hospital, Southern Medical University, Guangzhou, China
Find articles by Liu, S. in: PubMed | Google Scholar
1Institute of Molecular Immunology, Southern Medical University, Guangzhou, China
2School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4Medical Research Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
6Division of Vascular and Interventional Radiology, Department of General Su, Nanfang Hospital, Southern Medical University, Guangzhou, China
7Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
8Department of General Practice, Nanfang Hospital, Southern Medical University, Guangzhou, China
9Sleep and Brain Medicine Center, Shenzhen Hospital, Southern Medical University, Guangzhou, China
Find articles by Lu, Y. in: PubMed | Google Scholar
1Institute of Molecular Immunology, Southern Medical University, Guangzhou, China
2School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4Medical Research Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
6Division of Vascular and Interventional Radiology, Department of General Su, Nanfang Hospital, Southern Medical University, Guangzhou, China
7Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
8Department of General Practice, Nanfang Hospital, Southern Medical University, Guangzhou, China
9Sleep and Brain Medicine Center, Shenzhen Hospital, Southern Medical University, Guangzhou, China
Find articles by Wu, T. in: PubMed | Google Scholar
1Institute of Molecular Immunology, Southern Medical University, Guangzhou, China
2School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4Medical Research Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
6Division of Vascular and Interventional Radiology, Department of General Su, Nanfang Hospital, Southern Medical University, Guangzhou, China
7Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
8Department of General Practice, Nanfang Hospital, Southern Medical University, Guangzhou, China
9Sleep and Brain Medicine Center, Shenzhen Hospital, Southern Medical University, Guangzhou, China
Find articles by Geng, J. in: PubMed | Google Scholar
1Institute of Molecular Immunology, Southern Medical University, Guangzhou, China
2School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4Medical Research Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
6Division of Vascular and Interventional Radiology, Department of General Su, Nanfang Hospital, Southern Medical University, Guangzhou, China
7Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
8Department of General Practice, Nanfang Hospital, Southern Medical University, Guangzhou, China
9Sleep and Brain Medicine Center, Shenzhen Hospital, Southern Medical University, Guangzhou, China
Find articles by Chen, Q. in: PubMed | Google Scholar
1Institute of Molecular Immunology, Southern Medical University, Guangzhou, China
2School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4Medical Research Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
6Division of Vascular and Interventional Radiology, Department of General Su, Nanfang Hospital, Southern Medical University, Guangzhou, China
7Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
8Department of General Practice, Nanfang Hospital, Southern Medical University, Guangzhou, China
9Sleep and Brain Medicine Center, Shenzhen Hospital, Southern Medical University, Guangzhou, China
Find articles by Zhao, X. in: PubMed | Google Scholar
1Institute of Molecular Immunology, Southern Medical University, Guangzhou, China
2School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4Medical Research Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
6Division of Vascular and Interventional Radiology, Department of General Su, Nanfang Hospital, Southern Medical University, Guangzhou, China
7Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
8Department of General Practice, Nanfang Hospital, Southern Medical University, Guangzhou, China
9Sleep and Brain Medicine Center, Shenzhen Hospital, Southern Medical University, Guangzhou, China
Find articles by Zhao, J. in: PubMed | Google Scholar
1Institute of Molecular Immunology, Southern Medical University, Guangzhou, China
2School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4Medical Research Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
6Division of Vascular and Interventional Radiology, Department of General Su, Nanfang Hospital, Southern Medical University, Guangzhou, China
7Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
8Department of General Practice, Nanfang Hospital, Southern Medical University, Guangzhou, China
9Sleep and Brain Medicine Center, Shenzhen Hospital, Southern Medical University, Guangzhou, China
Find articles by Zhou, J. in: PubMed | Google Scholar
1Institute of Molecular Immunology, Southern Medical University, Guangzhou, China
2School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4Medical Research Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
6Division of Vascular and Interventional Radiology, Department of General Su, Nanfang Hospital, Southern Medical University, Guangzhou, China
7Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
8Department of General Practice, Nanfang Hospital, Southern Medical University, Guangzhou, China
9Sleep and Brain Medicine Center, Shenzhen Hospital, Southern Medical University, Guangzhou, China
Find articles by Hou, H. in: PubMed | Google Scholar
1Institute of Molecular Immunology, Southern Medical University, Guangzhou, China
2School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4Medical Research Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
6Division of Vascular and Interventional Radiology, Department of General Su, Nanfang Hospital, Southern Medical University, Guangzhou, China
7Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
8Department of General Practice, Nanfang Hospital, Southern Medical University, Guangzhou, China
9Sleep and Brain Medicine Center, Shenzhen Hospital, Southern Medical University, Guangzhou, China
Find articles by Ai, J. in: PubMed | Google Scholar
1Institute of Molecular Immunology, Southern Medical University, Guangzhou, China
2School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4Medical Research Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
6Division of Vascular and Interventional Radiology, Department of General Su, Nanfang Hospital, Southern Medical University, Guangzhou, China
7Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
8Department of General Practice, Nanfang Hospital, Southern Medical University, Guangzhou, China
9Sleep and Brain Medicine Center, Shenzhen Hospital, Southern Medical University, Guangzhou, China
Find articles by Tao, T. in: PubMed | Google Scholar
1Institute of Molecular Immunology, Southern Medical University, Guangzhou, China
2School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4Medical Research Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
6Division of Vascular and Interventional Radiology, Department of General Su, Nanfang Hospital, Southern Medical University, Guangzhou, China
7Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
8Department of General Practice, Nanfang Hospital, Southern Medical University, Guangzhou, China
9Sleep and Brain Medicine Center, Shenzhen Hospital, Southern Medical University, Guangzhou, China
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Published August 13, 2026 - More info
Copyright © 2026, Dong et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)