LCs express both CD1a and langerin in vivo. (A) Expression of langerin (left panels), CD1a (middle panels), and CD1b (right panels) in the epidermis (upper panels) and the dermis (lower panels) of the skin lesion of a leprosy patient. The images represent sections from the lesion of one patient showing the same region of the epidermis (upper panels) and the same granuloma (lower panels). Original magnification, ×200. (B) Colocalization of langerin and CD1a in the epidermis of a leprosy skin lesion. The dotted line indicates the margin between the epidermis (top) and the dermis (bottom). Original magnification, ×200.