Possible role of autoantibodies in the pathophysiology of GM2 gangliosidoses
J. Clin. Invest. Akira Yamaguchi, et al. 113:200 doi:10.1172/JCI19639 [
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Figure 9IgG deposition in the cerebellar neurons of an SD patient. (
a and
b) H&E staining of cerebellar sections showed cells with typical ballooning. Arrows indicate enlarged cells with ganglioside storage. (
c and
d) Immunohistochemical staining of the cerebellum with alkaline phosphatase–labeled anti-IgG antibody. Arrows indicate cells with IgG deposition (stained as red). (
a and
c) Original magnification, ×200; (
b and
d) Original magnification, ×400. ML, molecular layer; Pc, Purkinje cells; GL, granular layer.
