Advertisement
ResearchIn-Press PreviewCardiologyImmunology
Open Access | 
10.1172/JCI194664
S100a9 lactylation triggers neutrophil trafficking and cardiac inflammation in myocardial ischemia/reperfusion injury
Xiaoqi Wang,1 Xiangyu Yan,1 Ge Mang,1 Yujia Chen,1 Shuang Liu,2 Jiayu Sui,3 Zhonghua Tong,1 Penghe Wang,3 Jingxuan Cui,1 Qiannan Yang,1 Yafei Zhang,3 Dongni Wang,1 Ping Sun,4 Weijun Song,3 Zexi Jin,3 Ming Shi,5 Peng Zhao,4 Jia Yang,3 Mingyang Liu,1 Naixin Wang,1 Tao Chen,1 Yong Ji,6 Bo Yu,1 and Maomao Zhang1
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Wang, X. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Yan, X. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Mang, G. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Chen, Y. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Liu, S. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Sui, J. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Tong, Z. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Wang, P. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Cui, J. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Yang, Q. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Zhang, Y. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Wang, D. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Sun, P. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Song, W. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Jin, Z. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Shi, M. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Zhao, P. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Yang, J. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Liu, M. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Wang, N. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Chen, T. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Ji, Y. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Yu, B. in: PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
4Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
5School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
6Harbin Medical University, Harbin, China
Find articles by Zhang, M. in: PubMed | Google Scholar
Published October 9, 2025 - More info
Copyright © 2025, Wang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)