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Obesity is associated with macrophage accumulation in adipose tissue
Stuart P. Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L. Leibel, Anthony W. Ferrante Jr.
Published in Volume 112, Issue 12
J Clin Invest. 2003; 112(12):1796–1808 doi:10.1172/JCI19246
This article Copyright © 2003, The American Society for Clinical Investigation
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Figure 1

Adipose tissue transcripts whose abundance was correlated with body mass in mice. The expression of more than 12,000 transcripts in parametrial and epididymal adipose tissue was monitored in C57BL/6J mice whose body mass varied secondary to sex, diet, or mutations in the agouti (Ay/+) or leptin (Lepob/ob) loci. Using Kendall’s τ, a nonparametric correlation metric, we identified 1,304 transcripts that correlated significantly with body mass when the false discovery rate was held to 0.03. Examples of adipose tissue transcripts whose expression correlated with body mass include (a) Csf1r and (b) CD68 antigen (Cd68), which correlated positively with body mass, (c) succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (Sdhb), and (d) ubiquinol–cytochrome c reductase subunit (Uqcr), which correlated negatively with body mass. Gray and black symbols denote female and male mice, respectively. +, lean; triangles, Ay/+; squares, DIO; circles, Lepob/ob mice.

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