TNF-α is a critical negative regulator of type 1 immune activation during intracellular bacterial infection
J. Clin. Invest. Anna Zganiacz, et al. 113:401 doi:10.1172/JCI18991 [Go to this article.]

Figure 2
Histopathologic changes in the lungs of B6-WT and TNF^–/– mice following pulmonary rBCG mycobacterial infection. B6-WT (a–e) and TNF^–/– mice (f–j) were sacrificed at days 27 (a, b, f, g) and 37 (c–e, h–j). Their lung tissue sections were stained with H&E (a, c, d, f, h, i) or were subject to ApopTag Plus immunostaining and methyl green counterstaining for identification of apoptosis (b, e, g, j). B, bronchus; NG, necrotic granuloma. Arrows show apoptotic cells. These histomicrographs are representative of the lungs from at least three mice per group per time. Magnification, ×20 (c, h) and ×400 (a, b, d–f, i, j).