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ResearchIn-Press PreviewImmunologyInfectious disease
Open Access | 
10.1172/JCI189607
Hepcidin sustains Kupffer cell immune defense against bloodstream bacterial infection via gut-derived metabolites in mice
Yihang Pan,1 Lihua Shen,2 Zehua Wu,1 Xueke Wang,1 Xiwang Liu,3 Yan Zhang,1 Qinyu Luo,4 Sijin Liu,5 Xiangming Fang,6 Qiang Shu,4 and Qixing Chen4
1Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Gastroenterology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Department of Cardiac Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
4Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
5Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
6Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Pan, Y. in: PubMed | Google Scholar
1Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Gastroenterology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Department of Cardiac Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
4Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
5Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
6Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Shen, L. in: PubMed | Google Scholar
1Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Gastroenterology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Department of Cardiac Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
4Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
5Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
6Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Wu, Z. in: PubMed | Google Scholar
1Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Gastroenterology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Department of Cardiac Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
4Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
5Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
6Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Wang, X. in: PubMed | Google Scholar
1Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Gastroenterology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Department of Cardiac Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
4Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
5Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
6Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Liu, X. in: PubMed | Google Scholar
1Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Gastroenterology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Department of Cardiac Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
4Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
5Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
6Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Zhang, Y. in: PubMed | Google Scholar
1Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Gastroenterology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Department of Cardiac Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
4Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
5Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
6Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Luo, Q. in: PubMed | Google Scholar
1Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Gastroenterology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Department of Cardiac Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
4Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
5Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
6Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Liu, S. in: PubMed | Google Scholar
1Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Gastroenterology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Department of Cardiac Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
4Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
5Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
6Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Fang, X. in: PubMed | Google Scholar
1Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Gastroenterology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Department of Cardiac Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
4Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
5Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
6Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Shu, Q. in: PubMed | Google Scholar
1Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Gastroenterology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Department of Cardiac Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
4Department of Clinical Research Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
5Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
6Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Chen, Q. in: PubMed | Google Scholar
Published July 3, 2025 - More info
Copyright © 2025, Pan et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)