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ResearchIn-Press PreviewHematologyMetabolism
Open Access | 
10.1172/JCI186065
TNFα impairs platelet function by inhibiting autophagy and disrupting metabolism via Syntaxin-17 downregulation
Guadalupe Rojas-Sanchez,1 Jorge Calzada-Martinez,1 Brandon McMahon,2 Aaron C. Petrey,3 Gabriela Dveksler,4 Gerardo P. Espino-Solis,5 Orlando Esparza,6 Giovanny Hernandez,6 Dennis Le,6 Eric P. Wartchow,7 Ken Jones,8 Lucas H. Ting,9 Catherine Jankowski,10 Marguerite R. Kelher,11 Marilyn Manco-Johnson,12 Marie L. Feser,13 Kevin D. Deane,13 Travis Nemkov,14 Angelo D'Alessandro,14 Andrew Thorburn,15 Paola Maycotte,16 José A. López,1 and Pavel Davizon-Castillo1
1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
Find articles by Rojas-Sanchez, G. in: PubMed | Google Scholar
1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
Find articles by Calzada-Martinez, J. in: PubMed | Google Scholar
1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
Find articles by McMahon, B. in: PubMed | Google Scholar
1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
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Petrey, A.
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1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
Find articles by Dveksler, G. in: PubMed | Google Scholar
1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
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1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
Find articles by Esparza, O. in: PubMed | Google Scholar
1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
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Hernandez, G.
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1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
Find articles by Le, D. in: PubMed | Google Scholar
1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
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1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
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1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
Find articles by Ting, L. in: PubMed | Google Scholar
1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
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1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
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1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
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1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
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1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
Find articles by Deane, K. in: PubMed | Google Scholar
1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
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1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
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1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
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1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
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1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
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1Research, Bloodworks Research Institute, Seattle, United States of America
2Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, United States of America
3Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, United States of America
4Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Laboratorio Nacional de Citometría de Flujo, Facultad de Medicina y Ciencia, Universidad Autónoma de Chihuahua, Chihuahua, Mexico
6Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantatio, University of Colorado Anschutz Medical Campus, Aurora, United States of America
7Electron Microscopy Laboratory, Children's Hospital Colorado, Aurora, United States of America
8Bioinformatics Solutions, LLC, Sheridan, United States of America
9Stasys Medical, Seattle, United States of America
10University of Colorado College of Nursing, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
11Department of Surgery, University of Colorado School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, United States of America
12Department of Pediatrics, Hemophilia and Thrombosis Center, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
13Division of Rheumatology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
14Biochemistry and Molecular Genetics Department, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
15Department of Pharmacology, University of Colorado-Anschutz Medical Campus, Aurora, United States of America
16Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
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Published June 10, 2025 - More info
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