The clearance of HDL phospholipid from plasma in human apoA-I transgenic mice injected with either anti-mEL or control IgG. Mice (n = 4 mice per group) were injected with either anti-mEL (diamonds) or control IgG (squares). One hour later mice were injected through the tail vein with [³H]methylcholine-DPPC–labeled HDL ([³H]-PC-HDL), and blood samples were obtained over a 6-hour period. Six microliters of plasma taken at each time point were counted, and data are expressed as fractions of the counts at 1 minute.