A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice
J. Clin. Invest. Giuseppina Pennesi, et al. 111:1171 doi:10.1172/JCI15155 [
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Figure 1Histopathological features of EAU in HLA TG mice. (
a) Normal eye. The retinal layers are ordered and well preserved. (
b) Disease score 2 in C57BL/10 mice immunized with IRBP. The retinal architecture is disorganized, inflammatory cell infiltration is present, and the photoreceptor layer is damaged. (
c) Disease score 3 in DR4 TG mice immunized with IRBP. Note extensive destruction of the photoreceptor cell layer. (
d) Very severe disease (score 4) in DR3 TG mice immunized with S-Ag. Note complete destruction of the photoreceptor cell layers including photoreceptor cells (H&E, ×200).
