SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury
J. Clin. Invest. Amy D. Bradshaw, et al. 107:1049 doi:10.1172/JCI12939 [Go to this article.]

Figure 1
Structure of SPARC protein. A ribbon diagram derived from crystallographic data shows the three modular domains of SPARC. Representative activities attributed to each domain are shown beneath the designated amino acids. The follistatin-like domain contains the peptide 2.1 (see ref. 1) shown in green and the (K)GHK angiogenic peptide (amino acids 114–130) shown in black. The E-C domain contains the amino acids 255–274 (peptide 4.2) shown in yellow. Adapted from Hohenester et al. (29) and the Brookhaven Protein Database (30), accession no. 1BM0 from Ref.1, with permission.