The de-adhesive activity of matricellular proteins: is intermediate cell adhesion an adaptive state?
J. Clin. Invest. Joanne E. Murphy-Ullrich, et al. 107:785 doi:10.1172/JCI12609 [
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Figure 1The stages of cell adhesion and induction of the intermediate adhesive state by matricellular proteins. During the process of adhesion, a cell undergoes attachment, spreading, and the formation of stress fibers and focal adhesions. With each stage the adhesive strength of the cell increases. We define de-adhesion as the transition from strong adherence to intermediate adherence, as characterized by the disassembly of stress fibers
