Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis
J. Clin. Invest. Martin Kolb, et al. 107:1529 doi:10.1172/JCI12568 [Go to this article.]

Figure 6
Fibrogenic responses in the lung after intratracheal injection of AdhIL-1β. (a) Numerous fibroblast foci were observed in the lung tissue 14 days after injection. Special staining methods demonstrated that cells in these foci were myofibroblasts (b, α-SMA immunohistochemistry), and synthesized collagen (c, Masson trichrome) and fibronectin (d, immunohistochemistry). Major collagen and fibronectin accumulation was noticed 3 weeks after injection of AdhIL-1β (e and f, Masson trichrome and fibronectin immunohistochemistry), and myofibroblasts were present in interstitial areas and along alveolar walls (g, α-SMA immunohistochemistry). The histological appearance of animals treated with control virus AdDL70 was normal (h, Masson trichrome). ×160 (a–d); ×50 (e–h).