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Research Article Free access | 10.1172/JCI116908

Vasodilation of rat retinal microvessels induced by monobutyrin. Dysregulation in diabetes.

Y D Halvorsen, S E Bursell, W O Wilkison, A C Clermont, M Brittis, T J McGovern, and B M Spiegelman

Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

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Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

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Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

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Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

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Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

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Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

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Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

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Published December 1, 1993 - More info

Published in Volume 92, Issue 6 on December 1, 1993
J Clin Invest. 1993;92(6):2872–2876. https://doi.org/10.1172/JCI116908.
© 1993 The American Society for Clinical Investigation
Published December 1, 1993 - Version history
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Abstract

1-Butyryl-glycerol (monobutyrin) is a simple lipid product of adipocytes with angiogenic activity. Recent studies have shown that the biosynthesis of this compound is tightly linked to lipolysis, a process associated with changes in blood flow. We now present data indicating that monobutyrin is an effective vasodilator of rodent blood vessels using a fluorescent retinal angiogram assay. The vasodilatory activity of monobutyrin is potent (ED50 = 3.3 x 10(-7) M), dose dependent, and stereospecific. Because diabetes represents a catabolic, lipolytic state with numerous vascular complications, we examined the action and regulation of monobutyrin in insulin-deficient diabetic rats. Serum levels of monobutyrin in streptozotocin-induced diabetic rats were greatly elevated compared to normal animals. At the same time, the retinal vessels of the diabetic animals develop a resistance to the vasodilatory activity of monobutyrin. These results demonstrate a role for monobutyrin in the control of vascular tone and suggest a possible involvement in the pathology of diabetes.

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