Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome.

H Kawaguchi; T Miyashita; H Herbst; G Niedobitek; M Asada; M Tsuchida; R Hanada; A Kinoshita; M Sakurai; N Kobayashi

doi:10.1172/JCI116721

Department of Virology, National Children's Medical Research Center, Tokyo, Japan.

Find articles by Kawaguchi, H. in: PubMed | Google Scholar

Department of Virology, National Children's Medical Research Center, Tokyo, Japan.

Find articles by Miyashita, T. in: PubMed | Google Scholar

Department of Virology, National Children's Medical Research Center, Tokyo, Japan.

Find articles by Herbst, H. in: PubMed | Google Scholar

Department of Virology, National Children's Medical Research Center, Tokyo, Japan.

Find articles by Niedobitek, G. in: PubMed | Google Scholar

Department of Virology, National Children's Medical Research Center, Tokyo, Japan.

Find articles by Asada, M. in: PubMed | Google Scholar

Department of Virology, National Children's Medical Research Center, Tokyo, Japan.

Find articles by Tsuchida, M. in: PubMed | Google Scholar

Department of Virology, National Children's Medical Research Center, Tokyo, Japan.

Find articles by Hanada, R. in: PubMed | Google Scholar

Department of Virology, National Children's Medical Research Center, Tokyo, Japan.

Find articles by Kinoshita, A. in: PubMed | Google Scholar

Department of Virology, National Children's Medical Research Center, Tokyo, Japan.

Find articles by Sakurai, M. in: PubMed | Google Scholar

Department of Virology, National Children's Medical Research Center, Tokyo, Japan.

Find articles by Kobayashi, N. in: PubMed | Google Scholar

Published in Volume 92, Issue 3 on September 1, 1993
J Clin Invest. 1993;92(3):1444–1450. https://doi.org/10.1172/JCI116721.
© 1993 The American Society for Clinical Investigation

Published September 1, 1993 - Version history

The clonal composition of EBV-infected cells was examined in three cases of EBV-associated hemophagocytic syndrome by analysis of the heterogeneity of terminal repetitive sequences in the EBV genome, indicating monoclonal expansion of EBV-infected cells in all cases. Involvement of T lymphoid cells was determined by in situ hybridization using 35S-labeled RNA probes specific for the small EBV-encoded nuclear RNAs, EBER1 and EBER2, in combination with immunostaining for the TCR-beta chain, CD45RO, CD20, CD30 and CD68 antigens in these three cases. The majority of lymphoid cells showing EBER transcripts were stained by antibodies against CD45RO and T cell receptor-beta. In contrast, EBER-specific signals were not detectable on B cells or hemophagocytic cells. These data support the concept that EBV-associated T cell proliferation is a primary feature of EBV-AHS.

Images.

Version 1 (September 1, 1993): No description

Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome.

H Kawaguchi, T Miyashita, H Herbst, G Niedobitek, M Asada, M Tsuchida, R Hanada, A Kinoshita, M Sakurai, and N Kobayashi

Article tools

Metrics

Go to

Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome.

H Kawaguchi, T Miyashita, H Herbst, G Niedobitek, M Asada, M Tsuchida, R Hanada, A Kinoshita, M Sakurai, and N Kobayashi

Article tools

Metrics

Go to

Sign up for email alerts