Article tools
  • View PDF
  • Cite this article
  • E-mail this article
  • Send a letter
  • Information on reuse
  • Standard abbreviations
  • Article usage
Author information
Need help?

Research Article

Use of mouse anti-rabies monoclonal antibodies in postexposure treatment of rabies.

C L Schumacher, B Dietzschold, H C Ertl, H S Niu, C E Rupprecht and H Koprowski

Wistar Institute, Philadelphia, Pennsylvania 19104.

Published September 1989

Immunization of mice and hamsters with a cocktail of mouse MAbs specific for rabies virus nucleocapsid protein and glycoprotein protected animals not only when challenged with a lethal dose of rabies virus after immunization, but also in post-exposure situations. Hamsters treated with the MAb cocktail 3 h after virus inoculation were completely protected from lethal rabies virus infection, and 80% of the animals survived when the MAb cocktail was given 36 h after virus challenge. The potential usefulness of this MAb cocktail for the postexposure treatment of human rabies is discussed.

Browse pages

Click on an image below to see the page. View PDF of the complete article