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Research Article Free access | 10.1172/JCI114260
Wistar Institute, Philadelphia, Pennsylvania 19104.
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Wistar Institute, Philadelphia, Pennsylvania 19104.
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Wistar Institute, Philadelphia, Pennsylvania 19104.
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Wistar Institute, Philadelphia, Pennsylvania 19104.
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Wistar Institute, Philadelphia, Pennsylvania 19104.
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Published September 1, 1989 - More info
Immunization of mice and hamsters with a cocktail of mouse MAbs specific for rabies virus nucleocapsid protein and glycoprotein protected animals not only when challenged with a lethal dose of rabies virus after immunization, but also in post-exposure situations. Hamsters treated with the MAb cocktail 3 h after virus inoculation were completely protected from lethal rabies virus infection, and 80% of the animals survived when the MAb cocktail was given 36 h after virus challenge. The potential usefulness of this MAb cocktail for the postexposure treatment of human rabies is discussed.