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Research Article Free access | 10.1172/JCI113564

Erythropoietin messenger RNA levels in developing mice and transfer of 125I-erythropoietin by the placenta.

M J Koury, M C Bondurant, S E Graber, and S T Sawyer

Division of Hematology, Vanderbilt University, Nashville, Tennessee 37232.

Find articles by Koury, M. in: PubMed | Google Scholar

Division of Hematology, Vanderbilt University, Nashville, Tennessee 37232.

Find articles by Bondurant, M. in: PubMed | Google Scholar

Division of Hematology, Vanderbilt University, Nashville, Tennessee 37232.

Find articles by Graber, S. in: PubMed | Google Scholar

Division of Hematology, Vanderbilt University, Nashville, Tennessee 37232.

Find articles by Sawyer, S. in: PubMed | Google Scholar

Published July 1, 1988 - More info

Published in Volume 82, Issue 1 on July 1, 1988
J Clin Invest. 1988;82(1):154–159. https://doi.org/10.1172/JCI113564.
© 1988 The American Society for Clinical Investigation
Published July 1, 1988 - Version history
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Abstract

Erythropoietin (EP) mRNA was measured in normal and anemic mice during fetal and postnatal development. Normal fetal livers at 14 d of gestation contained a low level of EP mRNA. By day 19 of gestation, no EP mRNA was detected in normal or anemic fetal livers or normal fetal kidneys, but anemic fetal kidneys had low levels of EP mRNA. Newborn through adult stage mice responded to anemia by accumulating renal and hepatic EP mRNA. However, total liver EP mRNA was considerably less than that of the kidneys. Juvenile animals, 1-4 wk old, were hyperresponsive to anemia in that they produced more EP mRNA than adults. Moreover, nonanemic juveniles had readily measured renal EP mRNA, whereas the adult level was at the lower limit of detection. Because of the very low level of fetal EP mRNA, placental transfer of EP was evaluated. When administered to the pregnant mouse, 125I-EP was transferred in significant amounts to the fetuses. These results indicate that in mice the kidney is the main organ of EP production at all stages of postnatal development and that adult kidney may also play some role in providing EP for fetal erythropoiesis via placental transfer of maternal hormone.

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