Scintigraphic distribution of complexes of antiinsulin antibodies and 123I-insulin. In vivo studies in rats.

F Sodoyez-Goffaux; J C Sodoyez; M Koch; N Dozio; E R Arquilla; B McDougall; C J De Vos; R von Frenckell

doi:10.1172/JCI113094

Find articles by Sodoyez-Goffaux, F. in: PubMed | Google Scholar

Find articles by Sodoyez, J. in: PubMed | Google Scholar

Find articles by Koch, M. in: PubMed | Google Scholar

Find articles by Dozio, N. in: PubMed | Google Scholar

Find articles by Arquilla, E. in: PubMed | Google Scholar

Find articles by McDougall, B. in: PubMed | Google Scholar

Find articles by De Vos, C. in: PubMed | Google Scholar

Find articles by von Frenckell, R. in: PubMed | Google Scholar

Published in Volume 80, Issue 2 on August 1, 1987
J Clin Invest. 1987;80(2):466–474. https://doi.org/10.1172/JCI113094.
© 1987 The American Society for Clinical Investigation

Published August 1, 1987 - Version history

Clearance of immune complexes made of antiinsulin antibodies and 123I-insulin was studied with scintillation scanning in anesthetized rats. Complexes made with purified guinea pig antiinsulin IgG2 (cytophilic isotype) were rapidly cleared by the liver whereas those made with IgG1 remained in the plasma, as did 123I-labeled IgG1 or IgG2 of control animals. Hepatic clearance of insulin-antiinsulin IgG complexes was not inhibited by either an excess of insulin or decomplementation, thereby ruling out interaction with insulin and C3b receptors. Insulin and guinea pig antiinsulin serum or its purified IgG isotypes formed large aggregates exceeding 5 IgG. Antiinsulin antibodies of diabetics, mostly IgG1 and IgG3 (cytophilic isotypes), formed complexes that either remained in plasma (small aggregates) or were cleared by the liver (large aggregates). In conclusion, clearance of insulin-antiinsulin IgG complexes is probably mediated by Fc gamma receptors on macrophages and requires cytophilic subclass composition and formation of large IgG aggregates.

Images.

Version 1 (August 1, 1987): No description

Scintigraphic distribution of complexes of antiinsulin antibodies and 123I-insulin. In vivo studies in rats.

F Sodoyez-Goffaux, J C Sodoyez, M Koch, N Dozio, E R Arquilla, B McDougall, C J De Vos, and R von Frenckell

Article tools

Metrics

Go to

Scintigraphic distribution of complexes of antiinsulin antibodies and 123I-insulin. In vivo studies in rats.

F Sodoyez-Goffaux, J C Sodoyez, M Koch, N Dozio, E R Arquilla, B McDougall, C J De Vos, and R von Frenckell

Article tools

Metrics

Go to

Sign up for email alerts