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Research Article Free access | 10.1172/JCI113092

Angiotensin II-noradrenergic interactions in renovascular hypertensive rats.

J B Zimmerman, D Robertson, and E K Jackson

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Published August 1, 1987 - More info

Published in Volume 80, Issue 2 on August 1, 1987
J Clin Invest. 1987;80(2):443–457. https://doi.org/10.1172/JCI113092.
© 1987 The American Society for Clinical Investigation
Published August 1, 1987 - Version history
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Abstract

This study tested the hypothesis that interactions of endogenous angiotensin II (AII) with the noradrenergic neuroeffector junction are important in renin-dependent hypertension. In the in situ blood-perfused rat mesentery, in normal rats exogenous AII potentiated mesenteric vascular responses to periarterial (sympathetic) nerve stimulation (PNS) more than vascular responses to exogenous norepinephrine (NE). In 2-kidney-1-clip (2K-1C) rats with renovascular hypertension mesenteric vascular responses to PNS and NE were greater than in sham-operated rats, and renovascular hypertension mimicked the effects of exogenous AII with respect to enhancing responses to PNS more than responses to NE. In 2K-1C rats, but not in sham-operated rats, 1-Sar-8-Ile-AII markedly suppressed vascular responses to PNS, without influencing responses to NE. Finally, 1-Sar-8-Ile-AII attenuated sympathetic nerve stimulation-induced neuronal spillover of NE in 2K-1C rats, but not in sham-operated rats. These data indicate that renovascular hypertension enhances noradrenergic neurotransmission, and that this enhancement is mediated in part by AII-induced facilitation of NE release.

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