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Research Article Free access | 10.1172/JCI113087

Renal bicarbonate reabsorption in the rat. II. Distal tubule load dependence and effect of hypokalemia.

G Capasso, P Jaeger, G Giebisch, V Guckian, and G Malnic

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First published August 1, 1987 - More info

Published in Volume 80, Issue 2 (August 1, 1987)
J Clin Invest. 1987;80(2):409–414. doi:10.1172/JCI113087.
Copyright © 1987, The American Society for Clinical Investigation.

Published August 1, 1987
Abstract

We studied two groups of rats acutely loaded with bicarbonate, control rats on a standard diet and rats kept on a K-free diet for 3 wk. Compared with controls, K-depleted rats had reduced fractional excretion of bicarbonate despite their elevated filtered bicarbonate load. Distal bicarbonate reabsorption increased in K-depleted rats. In the presence of almost identical early distal bicarbonate loads (481 +/- 40 pmol/min in controls and 444 +/- 50 pmol/min in K depletion), distal bicarbonate reabsorption was significantly enhanced in K depletion (247 +/- 17 pmol/min) as compared with controls (179 +/- 18 pmol/min). These values are significantly different from each other, and both are severalfold higher than bicarbonate reabsorption in nonloaded conditions. In conclusion, distal bicarbonate reabsorption is load dependent, and distal bicarbonate reabsorption is stimulated in K depletion.

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