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Abstract

This study was designed to examine whether prostaglandin E2 can directly affect sodium transport across isolated perfused rabbit renal collecting tubules. Changes in transepithelial potential and isotopic sodium fluxes in response to peritubular prostaglandin E2 were measured. In addition, changes in transepithelial potential of the outer medullary collecting tubule in response to prostaglandin E2 were also measured. With few exceptions, all rabbits received 5 mg/day desoxycorticosterone acetate for 4-11 days before experimentation. The results of the experiments show that: (a) prostaglandin E2 inhibits the negative transepithelial potential in the cortical collecting tubule as well as the outer medullary collecting tubule; (b) prostaglandin E2 inhibits net sodium transport out of the lumen by inhibiting efflux while backflux is unaffected; (c) prostaglandin E2 produces this inhibition within 15 min, and the effects are dose dependent and reversible. These results suggest that prostaglandin E2 may modulate sodium transport in vivo and may contribute to the final regulation of sodium excretion.

Authors

J B Stokes, J P Kokko

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Citation information

Citations to this article in year 1985 (9)

Title and authors Publication Year
Mineralocorticoid effect on K+ permeability of the rabbit cortical collecting tubule
JB Stokes, I Lee
Kidney International 1985
Independent action of prostaglandins and kinins on vasopressin-stimulated water flow
G Carvounis, CP Carvounis, LA Arbeit
Kidney International 1985
Control of sodium and potassium transport in the cortical collecting duct of the rat. Effects of bradykinin, vasopressin, and deoxycorticosterone
K Tomita, JJ Pisano, MA Knepper
Journal of Clinical Investigation 1985
Prostaglandins, thromboxanes and leukotrienes in clinical medicine
RD Zipser, G Laffi
The Western journal of medicine 1985
The effect of suppression of prostaglandin synthesis on renal function in rats with intact and reduced renal mass
D Rubinger, Y Frishberg, A Eldor, MM Popovtzer
Prostaglandins 1985
Potentiating effects of leukotriene B4 and prostaglandin E2 on urinary sodium excretion by the dog kidney
RL Hébert, C Lamoureux, P Sirois, P Braquet, GE Plantel
Prostaglandins, Leukotrienes and Medicine 1985
Enriched prostaglandin E-9 ketoreductase activity in outer medullary cells of the rabbit kidney
MJ Miller, MA Carroll, M Schwartzman, NR Ferreri, JC McGiff
Prostaglandins 1985
Role of prostaglandins in the renal handling of a salt load in essential hypertension
B Trimarco, A Simone, A Cuocolo, B Ricciardelli, M Volpe, P Patrignani, L Saccà, M Condorelli
The American Journal of Cardiology 1985
Biochemical Actions of Hormones
D Marver
Biochemical Actions of Hormones 1985

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