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Research Article Free access | 10.1172/JCI107331

Hyperlipidemia in Coronary Heart Disease I. LIPID LEVELS IN 500 SURVIVORS OF MYOCARDIAL INFARCTION

Joseph L. Goldstein, William R. Hazzard, Helmut G. Schrott, Edwin L. Bierman, and Arno G. Motulsky

Department of Medicine (Division of Medical Genetics, University Hospital, and Division of Metabolism and Gerontology, Veterans Administration Hospital), University of Washington, Seattle, Washington 98195

Department of Genetics, University of Washington, Seattle, Washington 98195

Find articles by Goldstein, J. in: PubMed | Google Scholar

Department of Medicine (Division of Medical Genetics, University Hospital, and Division of Metabolism and Gerontology, Veterans Administration Hospital), University of Washington, Seattle, Washington 98195

Department of Genetics, University of Washington, Seattle, Washington 98195

Find articles by Hazzard, W. in: PubMed | Google Scholar

Department of Medicine (Division of Medical Genetics, University Hospital, and Division of Metabolism and Gerontology, Veterans Administration Hospital), University of Washington, Seattle, Washington 98195

Department of Genetics, University of Washington, Seattle, Washington 98195

Find articles by Schrott, H. in: PubMed | Google Scholar

Department of Medicine (Division of Medical Genetics, University Hospital, and Division of Metabolism and Gerontology, Veterans Administration Hospital), University of Washington, Seattle, Washington 98195

Department of Genetics, University of Washington, Seattle, Washington 98195

Find articles by Bierman, E. in: PubMed | Google Scholar

Department of Medicine (Division of Medical Genetics, University Hospital, and Division of Metabolism and Gerontology, Veterans Administration Hospital), University of Washington, Seattle, Washington 98195

Department of Genetics, University of Washington, Seattle, Washington 98195

Find articles by Motulsky, A. in: PubMed | Google Scholar

Published July 1, 1973 - More info

Published in Volume 52, Issue 7 on July 1, 1973
J Clin Invest. 1973;52(7):1533–1543. https://doi.org/10.1172/JCI107331.
© 1973 The American Society for Clinical Investigation
Published July 1, 1973 - Version history
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Abstract

Plasma cholesterol and triglyceride levels were measured after an overnight fast in 500 consecutively studied 3-mo survivors of myocardial infarction. Virtually all patients under 60 yr of age (95% ascertainment) and a randomly chosen group of older survivors admitted to 13 Seattle hospitals during an 11 mo period were included. A comparison of their lipid values with those of 950 controls demonstrated that 31% had hyperlipidemia. These lipid abnormalities were most commonly found in males under 40 yr of age (60% frequency) and in females under 50 yr of age (60% frequency). Elevation in triglyceride levels with (7.8%) or without (15.6%) an associated elevation in cholesterol levels was three times more common in survivors than a high cholesterol level alone (7.6%). These results raise the possibility that hypertriglyceridemia may be as an important a risk factor for coronary atherosclerosis as hypercholesterolemia. The identification of hyperlipidemic survivors of myocardial infarction provided a unique source of probands for family studies designed to disclose the genetic origin of hyperlipidemia in coronary heart disease.

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