JCI - Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model

Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model

Marion A. Hofmann, Evanthia Lalla, Yan Lu, Michelle Ryu Gleason, Bonnie M. Wolf, Nozomu Tanji, Luis J. Ferran Jr., Brigitte Kohl, Vijay Rao, Walter Kisiel, David M. Stern, Ann Marie Schmidt

Published in Volume 107, Issue 6

J Clin Invest. 2001; 107(6):675–683 doi:10.1172/JCI10588

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Figure 1

Induction of HHcy accelerates atherosclerotic lesion area and complexity. Male apoE-null mice, 4 weeks of age, were fed (a, e) diet A, n = 30; (b, f) diet B, n = 30; (c, g) diet C, n = 30, or (d, h) diet D, n = 10, for 8 weeks. Mice were sacrificed, and dissection of the aortic tree was performed (scale bar, 2 mm) (a–d). Serial sections were prepared at the aortic sinus and stained with oil red O (scale bar, 50 μm) (e–h). Mean atherosclerotic lesion area (i) and complexity (j) ± SD are reported. (i) ^AP < 0.01 vs. diets A, C, and D. (j) ^BP < 0.01 in numbers of complex lesions vs. those observed in mice receiving diets A, C, or D. In i and j, all mice included in the experimental groups as indicated above were analyzed.