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Free access | 10.1172/JCI105830

An experimental renal acidification defect in patients with hereditary fructose intolerance: I. Its resemblance to renal tubular acidosis

R. Curtis Morris Jr.

Department of Medicine, University of California School of Medicine, San Francisco, California 94122

Department of Pediatrics, University of California School of Medicine, San Francisco, California 94122

Find articles by Morris, R. in: PubMed | Google Scholar

Published June 1, 1968 - More info

Published in Volume 47, Issue 6 on June 1, 1968
J Clin Invest. 1968;47(6):1389–1398. https://doi.org/10.1172/JCI105830.
© 1968 The American Society for Clinical Investigation
Published June 1, 1968 - Version history
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Abstract

In three unrelated patients with hereditary fructose intolerance (HFI), but in none of five normal subjects, the experimental administration of fructose invariably induced a reversible dysfunction of the renal tubule with biochemical and physiological characteristics of renal tubular acidosis. During a state of ammonium chloride-induced acidosis, (a) urinary pH was greater than six and the rate of excretion of net acid (titratable acid plus ammonium minus bicarbonate) was inappropriately low, (b) the glomerular filtration rate remained unchanged or decreased modestly, and (c) urinary excretion of titratable acid increased briskly with diuresis of infused phosphate, although urinary pH changed little. The tubular dysfunction, which also includes impaired tubular reabsorption of alpha amino nitrogen and phosphate, persisted throughout administration of fructose and disappeared afterward. The tubular dysfunction was not causally dependent on hypoglucosemia, ammonium chloride-induced acidosis or osmotic diuresis. Rather, it appeared causally related to the fructose-induced metabolic abnormality of patients with HFI. The causal enzymatic defect, the virtual absence of fructose-1-phosphate aldolase, occurs in the kidney as well as in the liver of patients with HFI.

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