Published in Volume
46, Issue 10
(October 1967)J Clin Invest.
1967, The American Society for
Brain Metabolism during Fasting*
Elliott P. Joslin Research Laboratory, Department of Medicine, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, MassachusettsElliott P. Joslin Research Laboratory, Department of Surgery, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts
‡ Investigator, Howard Hughes Medical Institute.
* Received for publication 17 April 1967 and in revised form 23 June 1967.
Published October 1967
Catheterization of cerebral vessels in three obese patients undergoing 5-6 wk of starvation demonstrated that β-hydroxybutyrate and acetoacetate replaced glucose as the predominant fuel for brain metabolism. A strikingly low respiratory quotient was also observed, suggesting a carboxylation mechanism as a means of disposing of some of the carbon of the consumed substrates.
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