Tet2 function and innate immune resistance to bacterial pneumonia

In this episode, Candice Quin explains how individuals with TET2-mutant CHIP are at increased risk of bacterial pneumonia due to innate immune impairments.

JCI’s Conversations with Giants in Medicine: Stanley Prusiner

In this episode, Ushma Neill talks with Dr. Stanley Prusiner. The discovery that a protein alone could be infectious, proposed by Stanley Prusiner of the University of California San Francisco, was considered heretical in 1982. Now considered orthodoxy, at that time scientists thought that the only infectious agents could be bacteria, viruses, fungi, and parasites. We now know that these proteins, termed prions, which acquire an alternative shape and coax their neighboring proteins to do the same, undergird a variety of neurodegenerative diseases. For his dogma-shattering work, Dr. Prusiner has been widely recognized, including with the 1997 Nobel Prize in Physiology or Medicine.

Prolonged transplant survival in preclinical models

In this episode, Leonardo Riella presents his manuscript detailing how a humanized mutein IL-2 selectively expands and boosts the function of mouse, non-human primate and human regulatory T cells, prolonging allograft survival.

A glycolysis/HIF1a axis in promoting G-MDSC activity and biofilm persistence during PJI is important

In this episode, Tammy Kielian, Kevin Garvin, Christopher Horn, and Prabhakar Arumugam describe how their study demonstrates the importance of a glycolysis/HIF1a axis in promoting G-MDSC anti-inflammatory activity and biofilm persistence during PJI.

JCI's Conversations with Giants in Medicine: Elias Zerhouni

Ushma Neill with the Journal of Clinical Investigation Series, Conversations with Giants in Medicine met Dr. Elias Zerhouni at the Lasker Awards in September of 2023 and jumped at the opportunity to be able to spend an hour with him. Zerhouni, who is Professor Emeritus at Johns Hopkins University and Vice Chairman and President of OPKO Health, is a radiologist by training, who focused much of his research on CT and MRI-based imaging methods to diagnose cancer and cardiovascular diseases. He notably served as the director of the US National Institutes of Health from 2002 to 2008 and later as president of global research and development at Sanofi.