Extracellular matrix protein laminin β1 and behaviors in mice

In this episode, Ceng Luo and Zhen-Zhen Li explain that extracellular matrix laminin β1 protects against neuropathic pain and related anxiodepression through integrin β1-dependent actin reorganization.

Zonulin-dependent loss of gut mucosal barrier and MIS-C

In this episode, the authors explain that in multisystem inflammatory syndrome in children (MIS-C), increased gastrointestinal mucosal permeability allows SARS-CoV-2 antigens in the GI tract to leak into the bloodstream, triggering cytokine storm and hyperinflammatory responses.

Hemophilia A and immune response

In this episode, Valder Arruda explains that depletion of the cytokine B cell activating factor in hemophilia A may provide a way to prevent or eradicate factor VIII inhibitors.

Efficient maternal to neonatal transfer of antibodies

In this episode, Michal Kovo explains that antenatal BNT162b2 mRNA vaccination induces a robust maternal humoral response that effectively transfers to the fetus, supporting the role of vaccination during pregnancy.

JCI’s Conversations with Giants in Medicine: Jesse Roth, Ron Kahn, and Jeff Flier

We shift our format this month to bring you three giants in medicine, Dr. Jesse Roth of the Feinstein Institutes for Medical Research, Dr. C. Ronald Kahn of the Joslin Diabetes Center at Harvard Medical School, and Dr. Jeffrey Flier of Harvard Medical School, as part of the JCI’s salute to the 100th anniversary of the discovery of insulin. Roth, Kahn, and Flier all played instrumental roles in the discovery and description of the insulin receptor and in elucidating the critical role it plays in diabetes. Enjoy the full interview with their anecdotes and to get a glimpse of their extraordinary camaraderie.