T cells prevent and treat graft-versus-host disease

In this episode, Marco Davila and Brian Betts explain that taking advantage of the differential expression of CD83, human CD83-targeted CAR T cells prevent and treat GVHD, as well as kill myeloid leukemia.

JCI's Conversations with Giants in Medicine: Jesse Roth

We take it for granted today that each hormone and other intercellular messenger have their own specific receptors. But this was not the case until the groundbreaking work of Jesse Roth and his colleagues. Roth is best known for his research on cell surface membrane receptors. His studies on the receptors for insulin, growth hormone, and adrenocorticotropic hormone (ACTH) in the early 1970s became the model for many others.

Microenvironmental Th9 and Th17 induce spreading in lung cancer

In this episode, Rajkumar Savai and colleagues explain that Th9 and Th17 lymphocytes induce lung cancer cell epithelial-mesenchymal transition via release of their signature cytokines, thereby promoting migration, vessel entry, and metastatic spreading.

2020 ASCI Presidential Address: W. Kimryn Rathmell, MD, PhD

Dr. Rathmell provides her 2020 Presidential Address in a video format.

2020 AAP Presidential Address: Mary E. Klotman, MD

Dr. Klotman provides her 2020 Presidential Address in a video format.