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Author's Take

In this video collection, authors of findings published in The Journal of Clinical Investigation present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.

Human pulmonary tuberculosis and doxycycline therapy

In this episode, Catherine Ong explains that adjunctive doxycycline with standard anti-TB treatment suppresses pathological MMPs in pulmonary tuberculosis patients.


Extracellular matrix protein laminin β1 and behaviors in mice

In this episode, Ceng Luo and Zhen-Zhen Li explain that extracellular matrix laminin β1 protects against neuropathic pain and related anxiodepression through integrin β1-dependent actin reorganization.


Zonulin-dependent loss of gut mucosal barrier and MIS-C

In this episode, the authors explain that in multisystem inflammatory syndrome in children (MIS-C), increased gastrointestinal mucosal permeability allows SARS-CoV-2 antigens in the GI tract to leak into the bloodstream, triggering cytokine storm and hyperinflammatory responses.


Hemophilia A and immune response

In this episode, Valder Arruda explains that depletion of the cytokine B cell activating factor in hemophilia A may provide a way to prevent or eradicate factor VIII inhibitors.


Efficient maternal to neonatal transfer of antibodies

In this episode, Michal Kovo explains that antenatal BNT162b2 mRNA vaccination induces a robust maternal humoral response that effectively transfers to the fetus, supporting the role of vaccination during pregnancy.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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