In this video collection, authors of findings published in The Journal of Clinical Investigation present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.
In this issue, Edward Thorp explains that AXL uniquely promotes a switch to glycolytic metabolism and inflammatory cytokine production by macrophages to worsen ventricular remodeling and lead to heart failure after myocardial infarction.
In this episode, Erwin Van Meir and Satoru Osuka eplain that glioma stem cells adapt to the toxicity of repeated irradiation by upregulating N-cadherin, and this resistance pathway can be antagonized by blocking the IGF1 receptor.
In this episode, Santiago Lamas and Verónica Miguel explain that strategies based on FAO-GOF may constitute powerful alternatives to combat fibrosis inherent to CKD.
In this episode, Ana Greka and Eriene-Heidi Sidhom explain that an investigation of cell-specific disease mechanisms in rare genetic disorder revealed Braf/Mapk as a candidate pathway for the treatment of kidney diseases.
In this episode, Jane Buckner explains a longitudinal analysis of acute COVID-19 ranging from mild to severe disease determining immune trajectories of recovery.