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Author's Take

In this video collection, authors of findings published in The Journal of Clinical Investigation present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.

Deimination restores inner retinal visual function in murine demyelinating disease

Sanjoy Bhattarcharya and Vittorio Porciatti of the University of Miami discuss the role of deimination, a post-translational protein modification, in retinal function. Highlights:

  • Demyelinating diseases, including multiple sclerosis, are frequently accompanied by vision loss.
  • Deimination is a protein modification that is impaired in the retinas of patients with demyelinating disease.
  • Using a rat model of demyelinating disease, the researchers demonstrated that loss of deimination impaired retinal function.
  • Restoration of deimination restored neurite outgrowth and retinal function, suggesting that deimination could be a therapeutic target.

PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking

Erwan Bezard and Laurent Groc of the University of Bordeaux discuss the effects of the post-synaptic density protein PSD-95 on the development of levodopa-induced dyskinesia. Highlights:

  • L-DOPA-induced dyskinesia (LID) is a major side effect of dopamine replacement therapy for Parkinson’s disease.
  • LID is associated with changes in D1 dopamine receptor (D1R) interactions at the striatal synapses.
  • Using rat and macaque models, Bezard, Groc, and colleagues demonstrated that the synaptic density protein PSD-95 alters the trafficking of D1R to the synapse.
  • Loss of PSD-95 in the striatum reduces the development and severity of LID.
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Copyright © 2021 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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