Frataxin deficiency and pulmonary hypertension

In this episode, Stephen Chan explains that genetic and acquired frataxin deficiency disrupts genomic integrity to induce endothelial senescence and represents a common mechanism for multiple pulmonary hypertension subtypes.

Regulation of proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy

In this episode, Farah Sheikh presents the identification of a desmosomal COP9 signalosome regulatory complex that restricts desmosomal proteome degradation and genetic cardiac desmosomal disease, arrhythmogenic right ventricular cardiomyopathy.

Thymosin β4 protects against aortic aneurysm

In this episode, Nicola Smart, Sonali Munshaw, and Susann Bruche present their findings that Thymosin β4 is a regulator of LRP1, which protects against aortic aneurysm by regulating PDGFRβ endocytosis and smooth muscle phenotype.

Impairing melanoma phenotype switching and potentiating antitumor immune responses

In this episode, Sonia del Rincón and Fan Huang explain that inhibiting the MNK1/2-eIF4E axis dampens melanoma plasticity and enhances response to anti-PD-1 immunotherapy.

Lipid-induced cell adhesion promotes nonalcoholic steatohepatitis pathogenesis

In this episode, Samar Ibrahim explains that lipotoxic stress enhances the expression of LSEC-VCAM-1, in part, through MLK3 signaling. Inhibition of VCAM-1 was salutary in murine NASH, and might serve as a potential therapeutic strategy for human NASH.