In this video collection, authors of findings published in The Journal of Clinical Investigation present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.
In this episode, Ali Abbara and colleagues discuss that the Kisspeptin receptor agonist, MVT-602, has greater potency and longer duration of action than native kisspeptin-54, and thus increased therapeutic potential to treat female reproductive disorders.
In this episode, Benjamin Singer and colleagues explain that maintenance DNA methylation at inflammatory gene loci is necessary to stabilize regulatory T cell identity and suppressive function during both development and lineage self-renewal.
In this episode, Ma Luo and colleagues discuss how the anti-PCS T cell responses and the immune environment induced by the PCS vaccine are key correlates of vaccine efficacy.
In this episode, James Crowe reports a pan-H7 influenza protective human antibody that recognizes an epitope in the hemagglutinin head domain interface and disrupts HA trimers.
In this episode, Christina Zielinski and Julia Matthias explain that sodium chloride generates anti-inflammatory human Th17 cell responses but is coopted by pro-inflammatory cytokines to amplify Th17 cell pathogenicity and autoimmunity.